High frequency of shared clonotypes in human B cell receptor repertoires
نویسندگان
چکیده
منابع مشابه
Persisting fetal clonotypes influence the structure and overlap of adult human T cell receptor repertoires
The diversity of T-cell receptors recognizing foreign pathogens is generated through a highly stochastic recombination process, making the independent production of the same sequence rare. Yet unrelated individuals do share receptors, which together constitute a "public" repertoire of abundant clonotypes. The TCR repertoire is initially formed prenatally, when the enzyme inserting random nucleo...
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ژورنال
عنوان ژورنال: Nature
سال: 2019
ISSN: 0028-0836,1476-4687
DOI: 10.1038/s41586-019-0934-8